[Coffeeseminar] Journal club 30.5. 09:05 " "

[Aaro Salosensaari]

Hello,

in next week's journal club (30.5.2019 ~09:05, in 2nd floor meeting 
room), I will present following advance publication:

Lee, M., Han, S. W. & Seok, J. Prediction of survival risks with 
adjusted gene expression through risk-gene networks. /Bioinformatics/ 
https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btz399/5490203 
<https://doi.org/10.1093/bioinformatics/btz399>

A couple of points of interest

* includes nice overview of traditional Cox-LASSO survival with variable 
selection

* recursive network construction by neighborhood search was a news 
concept to be and I thought it was quite interesting on its own

* "data adjustment" sounds weird, but in practice the authors propose to 
project the data to simpler linear model structure induced by the 
network, which at least conceptually sounds surprisingly similar but 
maybe numerically simpler than Bayesian projective inference variable 
selection which according Piironen, Paasiniemi and Vehtari 2018 
https://arxiv.org/abs/1810.02406 works well for prediction and feature 
selection

- best,

  Aaro

-- 
Aaro Salosensaari
Jatko-opiskelija / PhD student
Lahti Lab, https://openresearchlabs.github.io
University of Turku
aaro.salosensaari at utu.fi

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