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<div>Dear All,</div>
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</div>
<div>There are two PhD positions open in the Cell Fate lab (ÅAU cell </div>
<div>biology, PI: prof. Cecilia Sahlgren). For more information please see </div>
<div>the forwarded message below. The deadline for applications is March </div>
<div>19th, 2019 at 15.00 Finnish time.<br>
</div>
</div>
<div><br>
</div>
<div><br>
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<div>Åbo Akademi University invites applications for a fixed term position</div>
<div>as a PhD Student in Cell Biology starting 1.4.2019 within</div>
<div>SPACE-Project (42 months) and within BACE-Project (48 months)</div>
<div><br>
</div>
<div>Research group</div>
<div><br>
</div>
<div>The Cell Fate lab led by Professor Cecilia Sahlgren is focused on the</div>
<div>fundamental molecular mechanisms that guide cell fate and cell</div>
<div>organization in stem cell differentiation, tissue formation and in</div>
<div>disease such as cancer. Together with collaborators we utilize such</div>
<div>knowledge to develop material-based medical technologies to control</div>
<div>these mechanisms in regenerative and cancer therapies. Coordination of</div>
<div>cells through molecular cell signaling pathways is crucial for the</div>
<div>formation of functional tissues and signaling is often deregulated in</div>
<div>diseases such as cancer, allowing cells to acquire abnormal functions</div>
<div>and pathological remodeling of tissue architecture. The physical,</div>
<div>mechanical and chemical stimuli of the microenvironment also influence</div>
<div>cell signaling and cell fate decisions during development and disease</div>
<div>progression.</div>
<div><br>
</div>
<div>Project description</div>
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</div>
<div>We are seeking 2 ambitious PhD candidates to join our projects on</div>
<div>Spatiotemporal activation of cell functions (SPACE) 1.4.2019-31.8.2022</div>
<div>or Bioelectronic activation of cell functions (BACE)</div>
<div>1.4.2019-28.2.2023. These projects form an interdisciplinary approach</div>
<div>bringing together researchers within experimental physics and</div>
<div>molecular biology, in order to activate Notch signalling on demand.</div>
<div>The Notch signalling pathway is a seemingly simple signalling system</div>
<div>where the interaction between a ligand at the surface of one cell and</div>
<div>a receptor at the surface of another gives rise to one active</div>
<div>signalling fragment, which regulates target gene expression. Notch is</div>
<div>involved in cell fate specification during development, usually by</div>
<div>facilitating binary cell fate decisions or by maintaining stem cell</div>
<div>fate. Perturbation of the signalling cascade is a contributing factor</div>
<div>in the development of various diseases. Strictly organised, both</div>
<div>spatial and temporal, expression of different receptors and ligands is</div>
<div>essential for proper development of different organs, with each</div>
<div>consecutive activation of Notch driving a specific morphogenic</div>
<div>process. The possibility of controlling Notch receptor activation by</div>
<div>regulating ligand dose and the specific timing of activation will</div>
<div>enable us to better understand different developmental patterns.</div>
<div><br>
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<div>JOB REQUIREMENTS</div>
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<div>We are accepting applications from enthusiastic and highly talented</div>
<div>candidates who are interested in a dynamic, stimulating and ambitious</div>
<div>environment to perform their research and share their scientific</div>
<div>knowledge.</div>
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</div>
<div>We are looking for candidates that meet the following requirements</div>
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<div>•The candidate should have a MSc in molecular biology, cell biology,</div>
<div>or an equivalent area</div>
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<div>Personal qualities</div>
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<div>We are seeking a driven and pro-active applicant with good</div>
<div>communication and interpersonal skills. The applicant should be</div>
<div>confident in working independently, but value developing good working</div>
<div>relationships both within the research group and with collaborators.</div>
<div>Knowledge of basic cell and molecular biological techniques (e.g.</div>
<div>mammalian cell culture, Western Blotting, PCR) is required. Knowledge</div>
<div>in e.g. biophysics, synthetic biology, chemistry or engineering (with</div>
<div>strong molecular background) is an asset.</div>
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<div>CONDITIONS OF EMPLOYMENT</div>
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<div>We offer</div>
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<div>•A challenging job at a dynamic and ambitious environment and in an</div>
<div>enthusiastic international, interdisciplinary team.</div>
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</div>
<div>•Access to world class infrastructure in proteomics, metabolomics,</div>
<div>functional genomics, bioinformatics and bioimaging.</div>
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<div>•Support with your personal development and career planning.</div>
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<div>•Gross monthly salary is in accordance with the salary system of</div>
<div>Finnish universities based on levels 2 – 4 of the job demand level for</div>
<div>teaching and research personnel. In addition, a salary component based</div>
<div>on personal work performance is paid.</div>
<div><br>
</div>
<div>•Doctoral training programme at Åbo Akademi University</div>
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<div>SALARY</div>
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<div>The salary for PhD Student is in accordance with the Finnish</div>
<div>University salary system for teaching and research personnel job</div>
<div>demand levels 2-4, where the work specific salary component is</div>
<div>2011,17-2507,62€ per month. In addition, there is a salary component</div>
<div>based on personal work performance, which is at most 50.00% of the</div>
<div>base salary.</div>
<div><br>
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<div>APPLICATION</div>
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<div>Please submit your electronic application with enclosures below</div>
<div>(Submit application, www.abo.fi/jobb). The closing date for</div>
<div>applications is March 19th, 2019 at 15.00 Finnish time.</div>
<div><br>
</div>
<div>A free-format letter of application (in English)</div>
<div>Copies of the bachelor's and master’s degree diplomas, including the</div>
<div>study record (with grades)</div>
<div>Your CV (in English)<br>
</div>
<div>Copies of documents that support the candidates English language skills</div>
<div>Recommendation letter or contact details to references</div>
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<div>CONTACT INFORMATION</div>
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<div>For further information, please contact professor Cecilia Sahlgren,</div>
<div>group leader, Cell Biology, Faculty of Science and Engineering, Åbo</div>
<div>Akademi University, e-mail: cecilia.sahlgren@abo.fi or Marika</div>
<div>Sjöqvist, PhD, marika.sjoqvist@abo.fi</div>
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<div>Link to add:</div>
<div><a href="https://abo.rekrytointi.com/paikat/index.php?jid=179&key=&o=A_RJ&rspvt=7q8x3xyyvm8804cc8ws8soggkgs484w">https://abo.rekrytointi.com/paikat/index.php?jid=179&key=&o=A_RJ&rspvt=7q8x3xyyvm8804cc8ws8soggkgs484w</a><br>
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<div>***************<br>
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<div>
<div>Viestin välitti<br>
</div>
<div>Fanni Suomi</div>
<div>Biokemian kopo, TYK ry</div>
<div>biokemiankopo@tykry.fi<br>
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